HollisterStier Allergy offers the highest concentration of dog hair extract available, proven in studies to be more effective for diagnosis and treatment.1,2

Now Available! HollisterStier’s Ultrafiltered Dog Hair & Dander extract.

Ultrafiltered Dog is manufactured using an ultrafiltered aqueous extraction process for maximum concentration without precipitate formation. To ensure high concentration levels, we use up to 50 times as much raw material as regular extracts. The result is an efficacious dog extract which meets Practice Parameters dosage recommendation.4,6

Quick Facts about Ultrafiltered Dog

  • We use up to 50x the raw material to create Ultrafiltered Dog, which is the same as AP Dog.
  • Ultrafiltered Dog is produced at 1:650 w/v to ensure an equivalent dosage to AP Dog.
  • As with all of our products, Ultrafiltered Dog is prepared in phenol-free glycero-cocas.
  • Transitioning is simple for both practices and patients. When switching patients on maintenance immunotherapy with an established dose of AP Dog, follow the standard transition protocol as you would with any other allergy extract. Refer to the Product Insert for dosage recommendations & additional product details.
  • FDA views Ultrafiltered Dog and AP Dog as comparable products. As a result, we are required to phase out AP Dog. If you are a current AP Dog customer, your sales representative will contact you to discuss transitioning from AP Dog to Ultrafiltered Dog.

How to Order Ultrafiltered Dog

HollisterStier Allergy is currently transitioning from AP Dog to UF Dog. At this time, most AP Dog customers are able to order UF Dog from the ordering portal or by placing an order with customer service.

For those who are yet unable to order UF Dog, please continue ordering AP Dog and contact your sales representative with any questions. By 2024, all AP Dog customers will be transitioned to UF Dog, and UF dog will be made widely available.

Informational Resources for Ultrafiltered Dog

AP Dog is HollisterStier’s exclusive acetone precipitated dog hair extract.

4825 AP Dog Hair and Dander – Scratch 5 mL Glycerinated 1:100 w/v
AP Dog Hair and Dander – Bulk 10 mL, 50 mL Glycerinated 1:100 w/v

Because Can f 1 can be present in every home (even homes without pets)3, you must have an effective dose for diagnosing and treating patients. Practice Parameters recommend 15 mcg of Can f 14, and you can easily dilute AP Dog to this dose. To get an equivalent dose with a conventional dog hair extract, you’d have to use approximately 3 mLs per shot. Use AP Dog for an accurate diagnosis and great patient care and treatment.1

150 mcg/mL of Can f 1 is 30x more concentrated than the conventional average of 5 mcg/mL of Can f 11

Quick Facts about AP Dog

  • An effective diagnosis (and treatment) means you reach and benefit more patients. Extracts with lower concentrations could result in false negatives during diagnosis.
  • Publications, studies, and abstracts have demonstrated the performance of AP Dog for both diagnosis and treatment of dog sensitive patients.1,2
  • Manufactured using our exclusive Acetone Precipitated (AP) extraction process for maximum concentration and efficacy.
  • AP Dog is reconstituted without phenol. Phenol can denature the proteins in allergenic extracts.5

Informational Resources for AP Dog

AP Dog Information Sheet


1 J.C. Turbeyville, M. Nelson, C. Mikita. Discordance Between Conventional and Acetone Precipitated (AP) Dog Extract in Skin Prick Testing. The Journal of Allergy and Clinical Immunology, Volume 121, Issue 2 (2008). DOI: https://doi.org/10.1016/j.jaci.2007.12.234

2 Anne M. Lent, MD, Ronald Harbeck, PhD, Matthew Strand, PhD, Michael Sills, BS, Kimberly Schmidt, RN, BSN, Benjamin Efaw, MS, Terri Lebo, BS, and Harold S. Nelson, MD. Immunologic response to administration of standardized dog allergen extract at differing doses. The Journal of Allergy and Clinical Immunology, Volume 118, No. 6 (2006). DOI: 10.1016/j.jaci.2006.07.055

3 S.J. Arbes, R.D. Cohn, M. Yin, M.L. Mullenbert, W. Friedman, and D.C. Zeldin. Dog Allergen (Can f 1) and Cat Allergen (Fel d1) in US Homes: Results from the National Survey of Lead Allergens in Housing. The Journal of Allergy and Clinical Immunology, 114(1), 111-117 (2004). DOI: 10.1016/j.jaci.2004.04.036

4 Cox ET AL. Allergen Immunotherapy: A practice parameter third update. The Journal of Allergy and Clinical Immunology, January 2011. DOI: 10.1016/j.jaci.2010.09.034

5 H.S. Nelson. Preparing and mixing allergen vaccines for subcutaneous immunotherapy. R.F. Lockey, S.C. Bukantz, & J. Bousquet (Eds.), Allergens and allergen immunotherapy, 4th ed., p. 315, 2008.

6 Internal Data on File